The scs and scs′ Insulator Elements Impart a cis Requirement on Enhancer–Promoter Interactions

The scs and scs 9 Insulator Elements Impart a cis Requirement on Enhancer

sites from the Drosophila gypsy transposon and the The Xenopus rRNA enhancer activates its cognate chicken b-globin insulator, have been suggested. These promoter when the two elements are placed on oppoinclude higher order chromatin structure (Udvardy et al., site rings of dimeric catenanes. Here we show that 1985; Kellum and Schedl, 1991; Vasquez and Schedl, when scs elements flank either the...

New Properties of Drosophila scs and scs’ Insulators

Insulators are defined as a class of regulatory elements that delimit independent transcriptional domains within eukaryotic genomes. The first insulators to be identified were scs and scs', which flank the domain including two heat shock 70 genes. Zw5 and BEAF bind to scs and scs', respectively, and are responsible for the interaction between these insulators. Using the regulatory regions of ye...

Spinal Cord Stimulation (SCS)

Spinal Cord Stimulation (SCS)

Spinal Cord Stimulation (SCS)